Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

Hyperbaric environment up-regulates CD15s expression on leukocytes, down-regulates CD77 expression on renal cells and up-regulates CD34 expression on pulmonary and cardiac cells in rat

Objective(s): The aim of this study was to estimate effects of hyperbaric (HB) treatment by determination of CD15s and CD11b leukocyte proinflammatory markers expression.  In addition, this study describes changes in CD77 and CD34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. Materials and Methods:Expression of CD11b and CD...

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.

RATIONALE Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator-activated receptor (PPAR)α and under normal conditions accounts for 70% of cardiac ATP content. Reduced Ppara expression during sepsis and heart failure leads to reduced fatty acid oxidation and myocardial energy deficiency. Many of the transcriptional regulators of Ppara are unknown. OBJECTIVE To determi...

hyperbaric environment up-regulates cd15s expression on leukocytes, down-regulates cd77 expression on renal cells and up-regulates cd34 expression on pulmonary and cardiac cells in rat

objective(s): the aim of this study was to estimate effects of hyperbaric (hb) treatment by determination of cd15s and cd11b leukocyte proinflammatory markers expression.  in addition, this study describes changes in cd77 and cd34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. materials and methods:expression of cd11b and cd...

Calorie Restriction, Longevity and Cognitive Function

cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2

Results Impaired mitochondrial respiration was observed in advanced stage dilative 9wk TAC hearts, associated with down-regulation of PGC1a, but not in 1-3 wk TAC hearts. Delayed sildenafil treatment (100mg/kg/day) initiated after hypertrophy establishment (1-3 wk TAC) inhibited progression of remodeling up to 9wks, which was associated with restored PGC1a expression and preserved mitochondrial...